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Textbook of Ion Channels Volume I Fundamental Mechanisms and Methodologies

Textbook of Ion Channels Volume I Fundamental Mechanisms and Methodologies

The Textbook of Ion Channels is a set of three volumes providing a wide-ranging reference source on ion channels for students instructors and researchers. Ion channels are membrane proteins that control the electrical properties of neurons and cardiac cells; mediate the detection and response to sensory stimuli like light sound odor and taste; and regulate the response to physical stimuli like temperature and pressure. In non-excitable tissues ion channels are instrumental for the regulation of basic salt balance that is critical for homeostasis. Ion channels are located at the surface membrane of cells giving them the unique ability to communicate with the environment as well as the membrane of intracellular organelles allowing them to regulate internal homeostasis. Ion channels are fundamentally important for human health and diseases and are important targets for pharmaceuticals in mental illness heart disease anesthesia pain and other clinical applications. The modern methods used in their study are powerful and diverse ranging from single ion-channel measurement techniques to models of ion channel diseases in animals and human clinical trials for ion channel drugs. Volume I Part 1 covers fundamental topics such as the basic principles of ion permeation and selectivity voltage-dependent ligand-dependent and mechano-dependent ion channel activation mechanisms the mechanisms for ion channel desensitization and inactivation and basic ion channel pharmacology and inhibition. Volume I Part 2 offers a practical guide of cardinal methods for researching ion channels including heterologous expression and voltage-clamp and patch-clamp electrophysiology; isolation of native currents using patch clamping; modeling ion channel gating structures and its dynamics; crystallography and cryo-electron microscopy; fluorescence and paramagnetic resonance spectroscopy methods; and genetics approaches in model organisms. All three volumes give the reader an introduction to fundamental concepts needed to understand the mechanism of ion channels; a guide to the technical aspects of ion channel research; a modern guide to the properties of major ion channel families; and includes coverage of key examples of regulatory physiological and disease roles for ion channels. | Textbook of Ion Channels Volume I Fundamental Mechanisms and Methodologies

GBP 89.99
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Siting Noxious Facilities Integrating Location Economics and Risk Analysis to Protect Environmental Health and Investments

Siting Noxious Facilities Integrating Location Economics and Risk Analysis to Protect Environmental Health and Investments

Siting Noxious Facilities explains and illustrates processes and criteria used to site noxious manufacturing and waste management facilities. It proposes a framework that integrates economic location analysis and risk analysis emphasizing the reduction of uncertainty. This book begins by defining noxious facilities and considers the important role of manufacturing in the world economy before going on to describe the historical practices used in locating these facilities for much of the twentieth century. It then shifts focus to analyze the complex set of considerations in the twenty-first century that mean that any facility that produces annoying smells and sounds is unsightly and emits hazardous substances has had the bar of acceptability markedly raised for economic environmental social and political acceptability. Drawing on case study examples that highlight pollution prevention choosing locations at major plants (CLAMP) negotiations and surrendering control of an activity Greenberg presents a hybrid framework that advocates the amalgamation of industrial location processes with human health and environmental-oriented risk analysis. This book will be of great interest to students and scholars of location economics environmental science risk analysis and land-use planning. It will also be of great relevance to decision-makers and their major advisers who must make choices about siting noxious facilities. | Siting Noxious Facilities Integrating Location Economics and Risk Analysis to Protect Environmental Health and Investments

GBP 39.99
1