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Nature's Ideological Landscape A Literary and Geographic Perspective on its Development and Preservation on Denmark's Jutland Heath

The Life and Literary Pursuits of Allen Davenport

Redefining Innovation Embracing the 80-80 Rule to Ignite Growth in the Biopharmaceutical Industry

Redefining Innovation Embracing the 80-80 Rule to Ignite Growth in the Biopharmaceutical Industry

Most people marvel at the level of innovation demonstrated by the biopharmaceutical industry in bringing new products to the market – especially in the past 20 years. However there is a crisis looming in the industry that should be a concern to all of us who take for granted the constant pace at which new treatments and increasingly cures have emerged from the laboratories of current sector incumbents. In the book we examine the evolution of the biopharmaceutical industry to understand how it became what we term a unicorn industry with a unique US-centered business model that has led to multiple blockbuster products (aka unicorns) year after year. We explore how past success has created perceived barriers to innovation diversification beyond the chemical or biological-based biopharmaceutical product and highlight the warning signs of the industry’s decline. We define a potential pathway for transforming the industry’s business model by broadening the definition sources and enablers of innovation beyond the traditional biopharmaceutical product. We introduce and advocate for the 80-80 Rule - Being 80% confident that you will only be 80% right the first time should feel normal. The 80-80 Rule is a theme that emphasizes speed and willingness to embrace uncertainty and overcome internal barriers to change. It sets the standard for redefining innovation as a platform to reignite growth of the biopharmaceutical industry. | Redefining Innovation Embracing the 80-80 Rule to Ignite Growth in the Biopharmaceutical Industry

GBP 31.99
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Food Phytates

Beyond Liberalism

Beyond Liberalism

In Beyond Nihilism Michael Polanyi argued that a merely negative liberty of doing as one pleases so long as one does not impinge upon the equal liberty of others - must and has led to destructive nihilism and a fierce reaction to collectivism. R. T. Allen takes up this argument in Beyond Liberalism and shows how Polanyi's political philosophy evolved into a more positive and distinctly conservative concept of liberty converging upon the archetypal conservatism of Edmund Burke. Allen examines Polanyi's and F. A. Hayek's thinking with respect to the nature value and foundations of liberty. Negative and positive liberties are two sides of one liberty and Allen believes negative conceptions of liberty are as dangerous as positive ones. He distinguishes among general and abstract definitions of liberty and shows how all including that of Hayek ultimately dissolve. According to Allen only tacit conceptions of liberty such as those of Burke and Polanyi prove viable. This is because they rest on concrete tradition. Allen examines how the skeptical rationalist and utilitarian philosophies of Ludwig von Mises and Sir Karl Popper fail to support the value of liberty and even proved to be destructive of it. Allen argues that society cannot rely upon the classically liberal notion of contract but rather upon prescriptive and inherited obligations. In turn this means that citizens have positive as well as negative duties to each other and the body politic of which they are part and upon whose support liberty depends. A free society is held together by emotional bonds and the traditions and rituals that sustain them. A free society also presupposes that the individual has inherent value in and for himself. For R. T. Allen only Christianity and certainly no modern philosophy has a conception of the unique individual and his irreplaceable value and of a political order that transcends itself into the moral order. Even Polanyi's liberty is ultimately insufficient for it gives no inherent value to the person himself but instead to the ideals which he serves. Beyond Liberalism challenges deeply ingrained notions of liberty and its meaning in modern society. It is a call for traditions of self-restraint and justice for their own sakes. This noteworthy volume is an essential addition to the libraries of political scientists philosophers and theologians alike.

GBP 42.99
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Preparation for Life? Vocationalism and the Equal Opportunities Challenge

The Cia's Secret Operations Espionage Counterespionage And Covert Action

The Productive Graduate Student Writer How to Manage Your Time Process and Energy to Write Your Research Proposal Thesis and Dissertatio

The Productive Graduate Student Writer How to Manage Your Time Process and Energy to Write Your Research Proposal Thesis and Dissertatio

This book is for graduate students-and others-who want to become more productive writers. It's especially written for those who want to:• increase their motivation focus and persistence to move a project to completion• overcome procrastination and perfectionistic tendencies• reduce (or write in spite of) their anxiety and fear of writing• manage their time work energy (and advisor) for greater productivityThe process or craft of sustained writing is not a matter that’s taught to undergraduate or graduate students as part of their studies leaving most at sea about how to start a practice that is central to a career in academe and vital in many other professional occupations. This book grew out of conversations Jan Allen has held with her graduate students for over 30 years and reflects the fruit of the writing workshops and boot camps she has conducted at three universities her own and numerous colleagues’ experiences with writing and advising as well as the feedback she receives from her popular Productive Writer listserv. While Jan Allen recognizes that writing is not an innate talent for most of us she demonstrates that it is a process based on skills which we can identify learn practice and refine. She focuses both on the process and habits of writing as well as on helping you uncover what kind of writer are you and reflect on your challenges and successes. With a light touch and an engaging sense of humor she proposes strategies to overcome procrastination and distractions and build a writing practice to enable you to become a more productive and prolific writer. Jan Allen proposes that you read one of her succinct chapters – each devoted to a specific strategy or writing challenge – each day or once a week. When you find one that increases your concentration motivation or endurance make it a habit. Try it for two weeks charting the resulting increased productivity. It will become part of your repertoire of writing and productivity tools to which you can progressively add. | The Productive Graduate Student Writer How to Manage Your Time Process and Energy to Write Your Research Proposal Thesis and Dissertatio

GBP 21.99
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Dictionary of Twentieth-Century British Cartoonists and Caricaturists

Philosophical Foundations for the Curriculum

Fitting Statistical Distributions The Generalized Lambda Distribution and Generalized Bootstrap Methods

Fitting Statistical Distributions The Generalized Lambda Distribution and Generalized Bootstrap Methods

Throughout the physical and social sciences researchers face the challenge of fitting statistical distributions to their data. Although the study of statistical modelling has made great strides in recent years the number and variety of distributions to choose from-all with their own formulas tables diagrams and general properties-continue to create problems. For a specific application which of the dozens of distributions should one use? What if none of them fit well?Fitting Statistical Distributions helps answer those questions. Focusing on techniques used successfully across many fields the authors present all of the relevant results related to the Generalized Lambda Distribution (GLD) the Generalized Bootstrap (GB) and Monte Carlo simulation (MC). They provide the tables algorithms and computer programs needed for fitting continuous probability distributions to data in a wide variety of circumstances-covering bivariate as well as univariate distributions and including situations where moments do not exist. Regardless of your specific field-physical science social science or statistics practitioner or theorist-Fitting Statistical Distributions is required reading. It includes wide-ranging applications illustrating the methods in practice and offers proofs of key results for those involved in theoretical development. Without it you may be using obsolete methods wasting time and risking incorrect results. | Fitting Statistical Distributions The Generalized Lambda Distribution and Generalized Bootstrap Methods

GBP 59.99
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Monte Carlo Methods and Models in Finance and Insurance

Monte Carlo Methods and Models in Finance and Insurance

Offering a unique balance between applications and calculations Monte Carlo Methods and Models in Finance and Insurance incorporates the application background of finance and insurance with the theory and applications of Monte Carlo methods. It presents recent methods and algorithms including the multilevel Monte Carlo method the statistical Romberg method and the Heath–Platen estimator as well as recent financial and actuarial models such as the Cheyette and dynamic mortality models. The authors separately discuss Monte Carlo techniques stochastic process basics and the theoretical background and intuition behind financial and actuarial mathematics before bringing the topics together to apply the Monte Carlo methods to areas of finance and insurance. This allows for the easy identification of standard Monte Carlo tools and for a detailed focus on the main principles of financial and insurance mathematics. The book describes high-level Monte Carlo methods for standard simulation and the simulation of stochastic processes with continuous and discontinuous paths. It also covers a wide selection of popular models in finance and insurance from Black–Scholes to stochastic volatility to interest rate to dynamic mortality. Through its many numerical and graphical illustrations and simple insightful examples this book provides a deep understanding of the scope of Monte Carlo methods and their use in various financial situations. The intuitive presentation encourages readers to implement and further develop the simulation methods.

GBP 42.99
1

The Radio Station Broadcasting Podcasting and Streaming

Favorite Counseling and Therapy Techniques

English for Journalists Thirtieth Anniversary Edition

Food-Drug Synergy and Safety

Food-Drug Synergy and Safety

Scientists health professionals and consumers are increasingly interested in the relationships between food components and food-drug combinations as they strive to find more effective ways to prevent or treat chronic disease. As one of the first unified and in-depth sources in this emerging topic Food-Drug Synergy and Safety explores the vast potential benefits of food and food-drug synergy. The book addresses the interaction of two or more components within a single food between several foods or between foods and drugs consumed together in which the potential health benefit is greater than the effect of the single component food or drug. Each chapter follows a consistent framework and addresses the health benefits mechanisms of action and safety aspects pertaining to the food and food-drug synergies. Sections discuss food and food-drug synergies in the context of specific disease groups such as cardiovascular disease cancer osteoporosis inflammatory diseases hypertension and obesity for easy reference in a clinical setting. A separate section focuses entirely on performance enhancers including caffeine creatine and ephedrine/ephedra and their potential to influence human health in addition to ergogenic applications. The final section provides scientists with a framework for designing experiments that elucidate the heath benefits and safety aspects of food and food-drug synergies. Food-Drug Synergy and Safety lays the essential foundation in this new direction of research as it gains momentum in the fields of food nutrition medicine and pharmaceutical sciences.

GBP 56.99
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The Bohemian Ethos Questioning Work and Making a Scene on the Lower East Side

Strategic Management From Theory to Practice

Solving Critical Design Problems Theory and Practice

State Energy Policy Current Issues Future Directions

Statistical Simulation Power Method Polynomials and Other Transformations

Statistical Simulation Power Method Polynomials and Other Transformations

Although power method polynomials based on the standard normal distributions have been used in many different contexts for the past 30 years it was not until recently that the probability density function (pdf) and cumulative distribution function (cdf) were derived and made available. Focusing on both univariate and multivariate nonnormal data generation Statistical Simulation: Power Method Polynomials and Other Transformations presents techniques for conducting a Monte Carlo simulation study. It shows how to use power method polynomials for simulating univariate and multivariate nonnormal distributions with specified cumulants and correlation matrices. The book first explores the methodology underlying the power method before demonstrating this method through examples of standard normal logistic and uniform power method pdfs. It also discusses methods for improving the performance of a simulation based on power method polynomials. The book then develops simulation procedures for systems of linear statistical models intraclass correlation coefficients and correlated continuous variates and ranks. Numerical examples and results from Monte Carlo simulations illustrate these procedures. The final chapter describes how the g-and-h and generalized lambda distribution (GLD) transformations are special applications of the more general multivariate nonnormal data generation approach. Throughout the text the author employs Mathematica® in a range of procedures and offers the source code for download online. Written by a longtime researcher of the power method this book explains how to simulate nonnormal distributions via easy-to-use power method polynomials. By using the methodology and techniques developed in the text readers can evaluate different transformations in terms of comparing percentiles measures of central tendency goodness-of-fit tests and more. | Statistical Simulation Power Method Polynomials and Other Transformations

GBP 64.99
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United Artists

Landmark Essays on Rhetoric of Science: Issues and Methods