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Bench to Bedside Diagnostic Microbiology for the Clinicians

Geriatric Rehabilitation From Bedside to Curbside

Translational Medicine Strategies and Statistical Methods

Translational Medicine Strategies and Statistical Methods

Examines Critical Decisions for Transitioning Lab Science to a Clinical SettingThe development of therapeutic pharmaceutical compounds is becoming more expensive and the success rates for getting such treatments approved for marketing and to the patients is decreasing. As a result translational medicine (TM) is becoming increasingly important in the healthcare industry – a means of maximizing the consideration and use of information collected as compounds transition from initial lab discovery through pre-clinical testing early clinical trials and late confirmatory studies that lead to regulatory approval of drug release to patients. Translational Medicine: Strategies and Statistical Methods suggests a process for transitioning from the initial lab discovery to the patient’s bedside with minimal disconnect and offers a comprehensive review of statistical design and methodology commonly employed in this bench-to-bedside research. Documents Alternative Research Approaches for Faster and More Accurate Data Judgment CallsElaborating on how to introduce TM into clinical studies this authoritative work presents a keen approach to building executing and validating statistical models that consider data from various phases of development. It also delineates a truly translational example to help bolster understanding of discussed concepts. This comprehensive guide effectively demonstrates how to overcome obstacles related to successful TM practice. It contains invaluable information for pharmaceutical scientists research executives clinicians and biostatisticians looking to expedite successful implementation of this important process. | Translational Medicine Strategies and Statistical Methods

GBP 59.99
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Gamma Cameras for Interventional and Intraoperative Imaging

Imaging in Critical Care Medicine

The Voices and Rooms of European Bioethics

The Voices and Rooms of European Bioethics

This book reflects on the many contributions made in and to European bioethics to date in various locations and from various disciplinary perspectives. In so doing the book advances understanding of the academic and social status of European bioethics as it is being supported and practiced by various disciplines such as philosophy law medicine and the social sciences applied to a wide range of areas. The European focus offers a valuable counter-balance to an often prominent US understanding of bioethics. The volume is split into four parts. The first contains reflection on bioethics in the past present and future and also considers how comparison between countries and disciplines can enrich bioethical discourse. The second looks at bioethics in particular locations and contexts including: policy boardrooms and courtrooms; studios and virtual rooms; and society while the third part explores the translation of theories and concepts of bioethics into the clinical setting. The fourth and final section focuses on academic expressions of bioethics as it is theorised in various disciplines and also as it is taught whether in classrooms or at the patient’s bedside. The book features unique contributions from a range of experts including: Alastair V Campbell; Ruth Chadwick; Angus Dawson; Raymond G. De Vries; Suzanne Ost; Renzo Pegoraro; Rouven Porz; Paul Schotsmans; Jochen Vollmann; Guy Widdershoven and Hub Zwart. Chapter 10 of this book ''You Don't Need Proof When You've Got Instinct!': Gut Feelings and Some Limits to Parental Authority' by Giles Birchley is available under an open access CC BY NC ND license and can be viewed at: http://www. tandfebooks. com/userimages/ContentEditor/1438250845242/9780415737197_chapter10. pdf . | The Voices and Rooms of European Bioethics

GBP 48.99
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Epilepsy Mechanisms Models and Translational Perspectives

Epilepsy Mechanisms Models and Translational Perspectives

Epilepsy has afflicted humankind throughout recorded history; yet it is only in the last half-century that significant progress has been made in our basic understanding of the epileptic brain. Pivotal advances in drug development and surgical techniques as well as the emergence of innovative approaches such as electrical stimulation of the nervous system have led to a substantial reduction in the morbidity and mortality of patients with epilepsy. At the same time remarkable developments in neuroscience have enhanced our understanding of brain structure and function. Epilepsy: Mechanisms Models and Translational Perspectives incorporates new translational advances that bring epilepsy therapies from the laboratory bench to the bedside and back again. It brings together the work of more than 70 of the field’s most respected and cutting-edge researchers and clinicians. In 24 chapters this extraordinarily comprehensive and current work:Offers an overview of the basic anatomic and functional substrates of seizure genesis and considers novel pathogenic concepts that have both emerged and been validated experimentallyExamines antiepileptic drug therapy including the latest on molecular targets Looks at the state of surgical treatments for epilepsy and discusses advances in the fields of structural and functional neuroimaging Reviews the variety of nontraditional therapeutic options such as the ketogenic diet the vagus nerve stimulator immunomodulators neurosteroids herbs and botanicals Investigates neuroendocrine hormonal and biobehavioral factors that influence seizure susceptibility—information that can be incorporated into the design of treatment algorithms on an individualized basis Provides a glimpse of what future epilepsy therapies might look like from novel mechanisms of drug delivery to gene and stem-cell therapies for epilepsy to seizure detection meth | Epilepsy Mechanisms Models and Translational Perspectives

GBP 59.99
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Learning from Disease in Pets A ‘One Health’ Model for Discovery

Learning from Disease in Pets A ‘One Health’ Model for Discovery

Learning from Disease in Pets: A ‘One Health’ Model for Discovery is the first encompassing reference guide for veterinarians researchers and physicians on conducting studies using spontaneous models of disease in animals. The study of naturally occurring disease in (pet) animals can help model our understanding of the biology prevention and therapy of human and animal diseases. Studies of pet dogs for instance can aid treatment of complex medical problems such as cancer orthopedic cardiopulmonary and neuro-inflammatory diseases and zoonotic infections. Each chapter within this novel cross-species approach is contributed by a leader or leaders in their field of research. Using clinical trials to learn how pets with real diseases respond to therapy can lead to breakthroughs in human medicine as well as benefiting pets suffering from otherwise debilitating illness. Despite similarities of diseases across species there are very few spontaneous models of disease used in research compared with models where disease is induced in healthy laboratory animals. Many medical researchers and veterinarians have a multitude of questions regarding how to use naturally occurring diseases in pets for the discovery of treatments and diagnostics: this book will demonstrate how to safely make this happen. This book encourages veterinarians to build on and disseminate existing findings for the wider benefit of pets and humans. Many pets suffering from incurable illnesses may benefit from clinical trials; the book includes a section on the imperative communication styles necessary within the research environment and with clients a compelling discussion on the ethics of using pets in veterinary clinical research comprehensive tables of diseases that spontaneously occur in animals and humans the regulatory requirements necessary to move therapy from benchside research to patient bedside as well as intricate details on how to design a robust clinical study. | Learning from Disease in Pets A ‘One Health’ Model for Discovery

GBP 82.99
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Biomedical Photonics Handbook Biomedical Diagnostics

Biomedical Photonics Handbook Biomedical Diagnostics

Shaped by Quantum Theory Technology and the Genomics Revolution The integration of photonics electronics biomaterials and nanotechnology holds great promise for the future of medicine. This topic has recently experienced an explosive growth due to the noninvasive or minimally invasive nature and the cost-effectiveness of photonic modalities in medical diagnostics and therapy. The second edition of the Biomedical Photonics Handbook presents fundamental developments as well as important applications of biomedical photonics of interest to scientists engineers manufacturers teachers students and clinical providers. The second volume Biomedical Diagnostics focuses on biomedical diagnostic technologies and their applications from the bench to the bedside. Represents the Collective Work of over 150 Scientists Engineers and Clinicians Designed to display the most recent advances in instrumentation and methods as well as clinical applications in important areas of biomedical photonics to a broad audience this three-volume handbook provides an inclusive forum that serves as an authoritative reference source for a broad audience involved in the research teaching learning and practice of medical technologies. What’s New in This Edition: A wide variety of photonic biochemical sensing technologies have already been developed for clinical monitoring of physiological parameters such as blood pressure blood chemistry pH temperature and the presence of pathological organisms or biochemical species of clinical importance. Advanced photonic detection technologies integrating the latest knowledge of genomics proteomics and metabolomics allow sensing of early disease state biomarkers thus revolutionizing the medicine of the future. Nanobiotechnology has opened new possibilities for detection of biomarkers of disease imaging single molecules and in situ diagnostics at the single cell level. In addition to these state-of-the art advancements the second edition contains new topics and chapters including: • Fiber Optic Probe Design • Laser and Optical Radiation Safety • Photothermal Detection • Multidimensional Fluorescence Imaging • Surface Plasmon Resonance Imaging • Molecular Contrast Optical Coherence Tomography • Multiscale Photoacoustics • Polarized Light for Medical Diagnostics • Quantitative Diffuse Reflectance Imaging • Interferometric Light Scattering • Nonlinear Interferometric Vibrational Imaging • Multimodality Theranostics Nanoplatforms • Nanoscintillator-Based Therapy • SERS Molecular Sentinel Nanoprobes • Plasmonic Coupling Interference Nanoprobes Comprised of three books: Volume I: Fundamentals Devices and Techniques; Volume II: Biomedical Diagnostics; and Volume III: Therapeutics and Advanced Biophotonics this second edition contains eight sections and provides introductory material in each chapter. It also includes an overview of the topic an extensive collection of spectroscopic data and lists of references for further reading. | Biomedical Photonics Handbook Biomedical Diagnostics

GBP 59.99
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