Bringing a Medical Device to the Market A Scientist’s Perspective Many of us in science have this Aha! moment when the mental puzzle is put together and you get a clear picture of a product which will change the world. Moreover you have a clear understanding of how it can be a commercial success. So you decide to start a new company a startup and have a clear path to success. However soon you come face to face with reality where things are much more complicated. Only a minute fraction of startups survives and becomes successful. This is particularly true in the complex world of medical devices. There are many good books on startups but this book is specifically about startups specializing in medical devices which are very different from other ones. It is written by a MedDev entrepreneur for first-time MedTech entrepreneurs. | Bringing a Medical Device to the Market A Scientist’s Perspective GBP 76.99 1
Biochemical Engineering A Laboratory Manual Biochemical engineering mostly deals with the most complicated life systems as compared with chemical engineering. A fermenter is the heart of biochemical processes. It is essential to operate a system properly. A description of enzymatic reaction kinetics is followed by cell growth kinetics to determine several kinetic parameters. Operations and analyses of several biochemical processes are included to determine their special. The book also covers the determination of several operational parameters such as volumetric mass transfer coefficient mixing time death rate constant chemical oxygen demand and heat of combustion. This book provides a novel description of the experimental protocol to find out several operational parameters of biochemical processes. A comprehensive collection of numerous experiments based on fundamentals it focuses on the determination of not only the characteristics of raw materials but also other essential parameters required for the operation of biochemical processes. It also emphasizes the applicability of the analysis to various processes. Equipped with illustrative diagrams neat flowcharts and exhaustive tables the book is ideal for young researchers teachers and scientists working towards developing a solid understanding of the experimental aspects of biochemical engineering. | Biochemical Engineering A Laboratory Manual GBP 76.99 1
Quantum Mechanics A Fundamental Approach The mathematical formalism of quantum theory in terms of vectors and operators in infinite-dimensional complex vector spaces is very abstract. The definitions of many mathematical quantities used do not seem to have an intuitive meaning which makes it difficult to appreciate the mathematical formalism and understand quantum mechanics. This book provides intuition and motivation to the mathematics of quantum theory introducing the mathematics in its simplest and familiar form for instance with three-dimensional vectors and operators which can be readily understood. Feeling confident about and comfortable with the mathematics used helps readers appreciate and understand the concepts and formalism of quantum mechanics. This book is divided into four parts. Part I is a brief review of the general properties of classical and quantum systems. A general discussion of probability theory is also included which aims to help in understanding the probability theories relevant to quantum mechanics. Part II is a detailed study of the mathematics for quantum mechanics. Part III presents quantum mechanics in a series of postulates. Six groups of postulates are presented to describe orthodox quantum systems. Each statement of a postulate is supplemented with a detailed discussion. To make them easier to understand the postulates for discrete observables are presented before those for continuous observables. Part IV presents several illustrative applications which include harmonic and isotropic oscillators charged particle in external magnetic fields and the Aharonov–Bohm effect. For easy reference definitions theorems examples comments properties and results are labelled with section numbers. Various symbols and notations are adopted to distinguish different quantities explicitly and to avoid misrepresentation. Self-contained both mathematically and physically the book is accessible to a wide readership including astrophysicists mathematicians and philosophers of science who are interested in the foundations of quantum mechanics. | Quantum Mechanics A Fundamental Approach GBP 116.00 1
Petroleum Refineries A Troubleshooting Guide In petroleum refineries although there are sets of standard operating procedures to operate the plants unique problems often arise which need to be tackled with engineering knowledge and experience without much loss of energy and time. This process is termed ‘troubleshooting’ and it saves production loss leading to profitability and sustainability of the refinery operation. This book covers the ins and outs of troubleshooting in petroleum refineries with an analysis of the problems faced the fundamentals behind them and logical reasoning and illustrations to solve the problems along with lessons learnt. This is the first such book on the market since the publication of one by Norman P. Lieberman about 30 years ago and there has been a massive change in technology since then. This book will not only enlighten practicing engineers in refineries and postgraduate students but also facilitate the creation of a knowledge bank on troubleshooting case studies helping share engineering knowledge and experiences. | Petroleum Refineries A Troubleshooting Guide GBP 116.00 1
Clinical Biochemistry A Laboratory Guide A knowledge of the practical aspects of clinical biochemistry is essential for medical students to understand the diagnostic and prognostic status of any ailment. This book addresses and compiles some of the invariably used protocols in biochemistry with the aim to enhance the understanding of the basics behind following the methodologies including those for urine analysis; carbohydrate protein and lipid analyses; and diabetes and lipid profile. It discusses organ function tests such as liver renal or pancreatic function tests in addition to exploring pH and buffer colorimeter spectrophotometer chromatography electrophoresis enzyme-linked adsorbent assay radioimmunoassay biosensor/glucometer fructosamine DNA isolation mass spectrometry flow cytometry centrifugation automation cerebrospinal fluid examination and oxalic acid test. The book also touches upon the basics of laboratory safety rules and laboratory glassware. The book is helpful for students to understand the relationship between quality management and specimen collection and processing them for their biological functions. It is well-suited for academic courses including undergraduate graduate postgraduate and professional courses and covers the practical syllabus for MBBS BDS BSc MLT BSc nursing and MSc students. For undergraduate students in the disciplines of biochemistry molecular biology chemistry and other related biological sciences the book forms an integral part of the syllabus with its case studies MCQs biochemistry OSPEs etc. It also demonstrates the actual experiments for understanding the concepts better and is a must read for students to acquire skills to work with a clinical biochemistry laboratory. | Clinical Biochemistry A Laboratory Guide GBP 76.99 1
Searching and Researching An Autobiography of a Nobel Laureate In the last 130 years 30 Swiss people have won a Nobel Prize and one of them is Richard R. Ernst. He laid the foundation for magnetic resonance imaging (MRI) which revolutionized medical diagnostics across the globe. In his autobiography which the scientist completed shortly before he passed away at the age of 87 he talks about his life. Prof. Ernst grew up in a family long-established in Winterthur Switzerland however his childhood and adolescence were overshadowed by a demanding father. He talks in detail about the start of his career in the 1960s when he made a number of key discoveries at Varian Associates Palo Alto USA as well as about his return to ETH Zürich Switzerland and the shark tank that university research is. The highly talented chemist reveals how his passion for Himalayan art began while travelling in Nepal which ended in him building up one of the most significant collections of thangkas – the tantric Buddhist scrolls. In this book Prof. Ernst discusses openly and directly about all aspects of his life with humility and a wry sense of humor. | Searching and Researching An Autobiography of a Nobel Laureate GBP 37.99 1
The Shroud of Christ Evidence of a 2 000 Year Antiquity The Shroud of Turin has been the focus of extensive study by historians and researchers since the beginning of the twentieth century. It is possibly the world’s most studied historical artifact generating a regular flow of new research publications. There is however one scientific test that overshadows all other research: the 1988 radiocarbon dating. This test dated the cloth to the period 1260–1390AD and was given such extensive publicity that most people today no longer accept the Shroud to be a true relic. Sadly very few people are aware that this test has been widely criticized for falling short of acceptable scientific standards. Similarly most people remain unaware of the wealth of compelling evidence that contradicts the conclusions of that test and supports claims of the Shroud’s authenticity. This book reveals extracts from secret discussions on dating evidence from the Shroud Science Group a private international forum of Shroud researchers and provides a detailed account of the dating evidence revealed by over a hundred years of research. It outlines reasons why the 1988 radiocarbon dating test continues to attract criticism from respected scientists and also describes a series of innovative flax dating techniques which have recently been used measure the age of Shroud material producing results that contradict the radiocarbon date. | The Shroud of Christ Evidence of a 2 000 Year Antiquity GBP 61.99 1
The Thermal Human Body A Practical Guide to Thermal Imaging This book is a guide for the constantly growing community of the users of medical thermal imaging. It describes where and how an infrared equipment can be used in a strictly standardised way and how one can ultimately comprehensively report the findings. Due to their insight into the complex mechanisms behind the distribution of surface temperature future users of medical thermal imaging should be able to provide careful and cautious interpretations of infrared thermograms thus avoiding the pitfalls of the past. The authors are well-known pioneers of the technique of infrared imaging in medicine who have combined strict standard-based evaluation of medical thermal images with their expertise in clinical medicine and related fields of health management. | The Thermal Human Body A Practical Guide to Thermal Imaging GBP 116.00 1
The Theory of Everything Quantum and Relativity is everywhere – A Fermat Universe The book unifies quantum theory and the general theory of relativity. As an unsolved problem for about 100 years and influencing so many fields this is probably of some importance to the scientific community. Examples like Higgs field limit to classical Dirac and Klein–Gordon or Schrödinger cases quantized Schwarzschild Kerr Kerr–Newman objects and the photon are considered for illustration. An interesting explanation for the asymmetry of matter and antimatter in the early universe was found while quantizing the Schwarzschild metric. | The Theory of Everything Quantum and Relativity is everywhere – A Fermat Universe GBP 37.99 1
A Triple Bottom Line Analysis of Global Consumption Economic Environmental and Social Effects of Pre-Pandemic World Trade 1990–2015 This book adds a whole new dimension to the editors’ previous work on the social economic and environmental effects of global trade. For the first time it brings all three pillars of sustainability together into one coherent multiregional input–output (MRIO) framework. It shows the power of MRIO analysis to illuminate the local and global interdependencies of economic environmental and social systems and the benefits to be gained through analysing all three together. Change one thing and everything else changes. With chapters from around 60 researchers across 34 countries this book illustrates the effect of natural resources and government policy settings 1990–2015 on the balancing act that was—and is—global trade. It provides a holistic systems’ view of how supply chains work revealing how easily they can become fragmented and out of kilter. And within all the chaos of COVID-19 it shows how MRIO is the one tool that can help rebuild a post-pandemic global economy into a fairer safer world. | A Triple Bottom Line Analysis of Global Consumption Economic Environmental and Social Effects of Pre-Pandemic World Trade 1990–2015 GBP 116.00 1
Companion Diagnostics (CDx) in Precision Medicine There is a new trend in anti-cancer therapeutics development: a targeted therapy and precision medicine that targets a subgroup of patients with specific biomarkers. An in vitro diagnostic (IVD) assay is required to identify a subgroup of cancer patients who would benefit from the targeted therapy or not likely benefit or have a high risk of side effects from the specific drug treatment. This IVD or medical device is called a companion diagnostic (CDx) assay. It is key to have a robust CDx assay or device for the success of targeted therapy and precision medicine. This book covers the technical historical clinical and regulatory aspects of CDx in precision medicine. Clearly more and more newly developed oncology drugs will require accompanying CDx assays and this book with chapters contributed by renowned oncologists provides a comprehensive foundation for the knowledge and application of CDx for precision medicine. | Companion Diagnostics (CDx) in Precision Medicine GBP 116.00 1
Physics and Future of Hurricanes This monograph is about hurricanes prompted by a discovery that suggests they will become more powerful with global warming. It provides at a college physics level a basic understanding of hurricanes emphasizing the flow of energy into and out of these storms and as a textbook covers some material that might be taught in meteorology or atmospheric physics courses. The text is centered on a new discovery that is not in any existing textbook. Because of the new discovery the book is of immediate interest to all meteorologists. It turns out that hurricanes as revealed by the new discovery are usefully regarded as a separate phase of matter bringing in characteristic temperature dependences near their transitions. The role of phase change in understanding hurricanes brings in the 20th-century discoveries in theoretical physics relating to critical phenomena with non-intuitive values of the critical exponent β entering the formula P = const (T – Tc)β where P is a characteristic strength parameter or order parameter of the phase of matter appearing at Tc. According to the new discovery on hurricanes it appears that taking the wind velocity as the order parameter P the critical exponent is near 1/3. In a second discovery we find that a small correction to this value is brought in by the complicated physics of the renormalization group that earned K. G. Wilson the Nobel Prize in Physics in 1982. | Physics and Future of Hurricanes GBP 53.99 1
Self-Aware Robots On the Path to Machine Consciousness This book focuses on the research and development in the field of self-aware robots. Its theme is artificial consciousness a field that covers both artificial intelligence and robotics and includes philosophy psychology the study of biological evolution physiology and medicine especially brain neuroscience and neuropsychiatry. Building on the first edition Creation of a Conscious Robot: Mirror Image Cognition and Self-Awareness this new edition discusses artificial neural networks and functions of human consciousness. It proposes a structure for a neural network with consciousness functions explains the construction of a conscious system and discusses the results of progressive research in designing and developing small robots with conscious systems capable of recognizing their own images in mirrors. Emphasizing the contributions of conscious robots to society and their potential future impact the book also describes the robots that know the unknown Pavlovian robots and the development of a consciousness model possessing the well-known multiple personality disorder. | Self-Aware Robots On the Path to Machine Consciousness GBP 100.00 1
Musical Spaces Place Performance and Power There is growing recognition and understanding of music’s fundamentally spatial natures with significances of space found both in the immediacy of musical practices and in connection to broader identities and ideas around music. Whereas previous publications have looked at connections between music and space through singular lenses (such as how they are linked to ethnic identities or how musical images of a city are constructed) this book sets out to explore intersections between multiple scales and kinds of musical spaces. It complements the investigation of broader power structures and place-based identities by a detailed focus on the moments of music-making and musical environments revealing the mutual shaping of these levels. The book overcomes a Eurocentric focus on a typically narrow range of musics (especially European and North American classical and popular forms) with case studies on a diverse set of genres and global contexts inspiring a range of ethnographic text-based historical and practice-based approaches. | Musical Spaces Place Performance and Power GBP 76.99 1
Nanomedicine in Cancer This book is the first in a series compiling highly cited articles in nanomedicine recently. The series is edited by Lajos P. Balogh a prominent nanotechnology researcher and journal editor. The first book content is about nanotechnology in cancer research. It also includes a wide variety of must-know topics that will appeal to any researcher involved in nanomedicine macromolecular science cancer therapy and drug delivery research. These 31 articles collected here have already acquired more than 3500 citations (i. e. over a hundred on average) highlighting the importance and recognized professional interest of the scientists working in this field. | Nanomedicine in Cancer GBP 347.00 1
Multifragmentation in Heavy-Ion Reactions Theory and Experiments This book provides a collection of reviews of some of the recent developments in nuclear physics research at intermediate energies from across the globe. It especially focuses on the most essential aspects such as multifragmentation and associated phenomena in nuclear collisions with the incident energy region between a few MeV and several hundreds of MeV/nucleon. The topic of the book—multifragmentation—was chosen based on the fact that all heavy-ion collisions revolve around a fragmenting system which is also thought to have a link to phase transitions. One unique and valuable dimension of this book is that it has brought together the research of several experts working in the field of intermediate energy heavy-ion collisions in various renowned laboratories of the world. It provides a thorough review of the recent developments in various related phenomena especially multifragmentation observed at the intermediate-energy range both theoretically and experimentally. It extensively discusses the concept of nuclear symmetry energy which is important for the nuclear physics and astrophysics communities. In addition the book identifies potential research directions and technologies that will drive future innovations. It will serve as a valuable reference for a larger audience including students who wish to pursue a career in nuclear physics and astrophysics. | Multifragmentation in Heavy-Ion Reactions Theory and Experiments GBP 154.00 1
Mobile Microspies Particles for Sensing and Communication On the one hand particle-based sensing techniques are driven by new technologies for preparing and measuring micro- and nanoparticles and by a fascination of the possibilities for design and functionalization of all specificities in structure shapes and behavior of these tiny objects. On the other hand there evolves a fast-growing need for new sensing and communication paths for medicine biotechnology and analytical science as well as for new and efficient information transfer and storage systems. No longer are particles regarded only as special types of materials. However we have a better understanding of how they are bridging the gap between material and system between structure and function. Although there are numerous books on micro- and nanoparticles and on sensors there is to the best of my knowledge no book focusing on the general concept of particles as mobile microtransducers. This book clarifies that signal-transducing particles should be regarded as functional elements as part of a system not simply as special materials. It introduces concepts of bead-base sensing and mobile spies at the micro- and nanoscale and gives a representative overview of the variety of particle-based sensing. The state of the art in the development of particles as mobile spies for communication and information management allows us to speculate about future particle-based components and systems in a completely sustainable world economy. In addition the book reports on a fast-evolving technical field which is a typical example of the required convergence of technical strategies and mechanisms in living nature and would make a great reference for professionals and students of chemistry biochemistry biology pharmacy medicine agriculture mechatronics informatics materials science and systems engineering. | Mobile Microspies Particles for Sensing and Communication GBP 100.00 1
Natural Food Preservatives Safety quality and prolonged shelf life of food products are the three most important aspects of the food industry. To ensure a satisfactory scale both traditional and modern preservatives are widely used. However as eating habits have upgraded with a focus on what is popularly termed a healthy diet there has been a growing demand for food with natural additives over synthetic ingredients. As a result there have been major developments in the field of food preservation which are presented in this book. The book provides detailed information on the range of natural food preservatives with their applications in different product sectors. It delves into microbiological food spoilage and discusses natural food preservatives as well as natural antioxidants and antimicrobials as food ingredients. It reviews prevalent preservation technologies the chemistry behind them and new nonconventional preservatives. It focuses on innovative technologies including biological antimicrobial systems such as LABs or their metabolites bacteriophages and bacteriophage-encoded enzymes. It provides knowledge about preservatives such as bacteriocins and ε-polylysine as well as their usage in achieving the right balance of safety quality and shelf-life for specific products. The book is a collection of the research and experiences of an international team of experts and is a valuable tool for all those who are related to the advancements and production of safe and healthy foods. It is a significant reference book for professionals who teach food microbiology courses conduct research and epidemiologic investigations analyze food samples and craft food safety policies. GBP 116.00 1
The Hip Joint Modified Posterior Approach This book summarizes the lifetime work of Dr K. Mohan Iyer and is based on his research done at the University of Liverpool UK where he devised a modified posterior approach to the hip joint and has been following it from 1981 till today. The book discusses the anterior approach to the hip on a standard operating table using a leg holder with a combined spinal anesthetic and general anesthetic. It studies total hip replacement as a day-case as an evolution in total hip replacement and presents the principles of anterior approach for total hip arthroplasty including discussions on the choice of patients superficial and deep dissection and dedicated surgical instruments. It provides extensive details on the direct anterior approach (DAA) and shows how the DAA to the hip can be carried out on a plain table which can be useful in countries in Asia such as India without the use of special operating tables and dedicated surgical instruments for the same. The book is helpful for the upcoming postgraduates in orthopedics anywhere in the world to be well versed in DAA to the hip joint. | The Hip Joint Modified Posterior Approach GBP 193.00 1
Plasmonics in Chemistry and Biology Over the past decade plasmonic nanoparticles have been the subject of extensive research owing to their remarkable optical properties. These properties arise from a collective oscillation of the conductive electrons at the nanoparticle surface under light irradiation known as localized surface plasmon (LSP). LSP is characterized by (i) a strong absorption and scattering of the light depending on the geometrical parameters of the nanoparticles and (ii) a strong amplification of the local field in the vicinity of the nanoparticles. Quite recently it was shown that the activation and the initiation of chemical reactions or physical processes can be facilitated using LSP excitation. Such exploitation presents two main advantages: an enhanced yield and a fine control of chemical reactions at the nanoscale. These topics have become very active and are in line with molecular plasmonics. This book explores this new field and provides a broad view on the exploitation of plasmonics in chemical and biological fields. | Plasmonics in Chemistry and Biology GBP 116.00 1
Cellular Analysis by Atomic Force Microscopy Despite substantial evidence showing the feasibility of Atomic Force Microscopy (AFM) to identify cells with altered elastic and adhesive properties the use of this technique as a complementary diagnostic method remains controversial. This book is designed to be a practical textbook that teaches how to assess the mechanical characteristics of living individual cells by AFM. Following a step-by-step approach it introduces the methodology of measurements in the case of both determination of elastic properties and quantification of adhesive properties. | Cellular Analysis by Atomic Force Microscopy GBP 95.00 1
From Atoms to Higgs Bosons Voyages in Quasi-Spacetime The announcement in 2012 that the Higgs boson had been discovered was understood as a watershed moment for the Standard Model of particle physics. It was deemed a triumphant event in the reductionist quest that had begun centuries ago with the ancient Greek natural philosophers. Physicists basked in the satisfaction of explaining to the world that the ultimate cause of mass in our universe had been unveiled at CERN Switzerland. The Standard Model of particle physics is now understood by many to have arrived at a satisfactory description of entities and interactions on the smallest physical scales: elementary quarks leptons and intermediary gauge bosons residing within a four-dimensional spacetime continuum. Throughout the historical journey of reductionist physics mathematics has played an increasingly dominant role. Indeed abstract mathematics has now become indispensable in guiding our discovery of the physical world. Elementary particles are endowed with abstract existence in accordance with their appearance in complicated equations. Heisenberg’s uncertainty principle originally intended to estimate practical measurement uncertainties now bequeaths a numerical fuzziness to the structure of reality. Particle physicists have borrowed effective mathematical tools originally invented and employed by condensed matter physicists to approximate the complex structures and dynamics of solids and liquids and bestowed on them the authority to define basic physical reality. The discovery of the Higgs boson was a result of these kinds of strategies used by particle physicists to take the latest steps on the reductionist quest. This book offers a constructive critique of the modern orthodoxy into which all aspiring young physicists are now trained that the ever-evolving mathematical models of modern physics are leading us toward a truer understanding of the real physical world. The authors propose that among modern physicists physical realism has been largely replaced—in actual practice—by quasirealism a problematic philosophical approach that interprets the statements of abstract effective mathematical models as providing direct information about reality. History may judge that physics in the twentieth century despite its seeming successes involved a profound deviation from the historical reductionist voyage to fathom the mysteries of the physical universe. | From Atoms to Higgs Bosons Voyages in Quasi-Spacetime GBP 76.99 1
Functional Materials Advances and Applications in Energy Storage and Conversion The world is currently facing the urgent and demanding challenges of saving and utilizing energy as efficiently as possible. Materials science where chemistry meets physics has garnered a great deal of attention because of its versatile techniques for designing and producing new desired materials enabling energy storage and conversion. This book is a comprehensive survey of the research on such materials. Unlike a monograph or a review book it covers a wide variety of compounds details diverse study methodologies and spans different scientific fields. It contains cutting-edge research in chemistry and physics from the interdisciplinary team of Ehime University (Japan) the members of which are currently broadening the horizon of materials sciences through their own ideas tailored equipment and state-of-the-art techniques. Edited by Toshio Naito a prominent materials scientist this book will appeal to anyone interested in solid-state chemistry organic and inorganic semiconductors low-temperature physics or the development of functional materials including advanced undergraduate- and graduate-level students of solid-state properties and researchers in metal-complex science materials science chemistry and physics especially those with an interest in (semi)conducting and/or magnetic materials for energy storage and conversion. | Functional Materials Advances and Applications in Energy Storage and Conversion GBP 139.00 1
Immunoassays Development Applications and Future Trends The concept behind this book is to provide a detailed and practical overview of the development and use of immunoassays in many different areas. Immunoassays are analytical tests that utilise antibodies to measure the amount activity or identity of an analyte. This book is designed to provide a critical and helpful insight into the subject and to give the user practical information that may be of assistance in assay format selection antibody generation/selection and choice of appropriate detection strategies. It is comprised of 13 chapters written by highly experienced researchers in the fields of antibody-based research immunoassay development assay validation diagnostics and microfluidics. Beginning with a comprehensive survey of antibodies immunoassay formats and signalling systems the book elucidates key topics related to the development of an ideal antibody-based sensor focuses on the important topic of surface modification explores key parameters in the immobilisation of antibodies onto solid surfaces discusses the move to ‘lab-on-a-chip’-based devices and investigates the key parameters necessary for their development. Three of the chapters are dedicated to the areas of clinical diagnostics infectious disease monitoring and food security where immunoassay-based applications have become highly valuable tools. The future of immunoassays including next-generation immunoassays electrochemical-immunoassays and ‘lab-on-a-chip’-based systems is also discussed. The book also covers the use of optical detection systems (with a focus on surface plasmon resonance) in immunoassays provides a compilation of important routinely used immunoassay protocols and addresses problems that may be encountered during assay development. | Immunoassays Development Applications and Future Trends GBP 159.00 1
Nano-Enabled Medical Applications This book is the second in a series presenting articles that received the most citations in recent years in nanomedicine. The series is edited by a prominent nanotechnology researcher and editor-in-chief of Precision Nanomedicine. The theme of the second volume is about nano-enabled medical applications. The 19 articles collected here have already acquired more than 12 500 citations highlighting the importance and professional recognition of the work of these scientists in nanomedicine. The content includes the general overview of the field and a wide variety of applications that have been impossible without nanoscience and nanotechnology. GBP 193.00 1