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Theoretical Statistics

Intelligent Cyber-Physical Systems Security for Industry 4.0 Applications Challenges and Management

Intelligent Cyber-Physical Systems Security for Industry 4.0 Applications Challenges and Management

Intelligent Cyber-Physical Systems Security for Industry 4. 0: Applications Challenges and Management presents new cyber-physical security findings for Industry 4. 0 using emerging technologies like artificial intelligence (with machine/deep learning) data mining applied mathematics. All these are the essential components for processing data recognizing patterns modeling new techniques and improving the advantages of data science. Features • Presents an integrated approach with Cyber-Physical Systems CPS security and Industry 4. 0 in one place • Exposes the necessity of security initiatives standards security policies and procedures in the context of industry 4. 0 • Suggests solutions for enhancing the protection of 5G and the Internet of Things (IoT) security • Promotes how optimization or intelligent techniques envisage the role of artificial intelligence-machine/deep learning (AI-ML/DL) in cyberphysical systems security for industry 4. 0 This book is primarily aimed at graduates researchers and professionals working in the field of security. Executives concerned with security management knowledge dissemination information and policy development for data and network security in different educational government and non-government organizations will also find this book useful. | Intelligent Cyber-Physical Systems Security for Industry 4. 0 Applications Challenges and Management

GBP 110.00
1

Advances in Distance Learning in Times of Pandemic

Advances in Distance Learning in Times of Pandemic

The book Advances in Distance Learning in Times of Pandemic is devoted to the issues and challenges faced by universities in the field of distance learning in COVID-19 times. It covers both the theoretical and practical aspects connected to distance education. It elaborates on issues regarding distance learning its challenges assessment by students and their expectations the use of tools to improve distance learning and the functioning of e-learning in the industry 4. 0 and society 5. 0 eras. The book also devotes a lot of space to the issues of Web 3. 0 in university e-learning quality assurance and knowledge management. The aim and scope of this book is to draw a holistic picture of ongoing online teaching-activities before and during the lockdown period and present the meaning and future of e-learning from students’ points of view taking into consideration their attitudes and expectations as well as industry 4. 0 and society 5. 0 aspects. The book presents the approach to distance learning and how it has changed especially during a pandemic that revolutionized education. It highlights • the function of online education and how that has changed before and during the pandemic. • how e-learning is beneficial in promoting digital citizenship. • distance learning characteristic in the era of industry 4. 0 and society 5. 0. • how the era of industry 4. 0 treats distance learning as a desirable form of education. The book covers both scientific and educational aspects and can be useful for university-level undergraduate postgraduate and research-grade courses and can be referred to by anyone interested in exploring the diverse aspects of distance learning.

GBP 110.00
1

Combinatorial Nullstellensatz With Applications to Graph Colouring

Combinatorial Nullstellensatz With Applications to Graph Colouring

Combinatorial Nullstellensatz is a novel theorem in algebra introduced by Noga Alon to tackle combinatorial problems in diverse areas of mathematics. This book focuses on the applications of this theorem to graph colouring. A key step in the applications of Combinatorial Nullstellensatz is to show that the coefficient of a certain monomial in the expansion of a polynomial is nonzero. The major part of the book concentrates on three methods for calculating the coefficients: Alon-Tarsi orientation: The task is to show that a graph has an orientation with given maximum out-degree and for which the number of even Eulerian sub-digraphs is different from the number of odd Eulerian sub-digraphs. In particular this method is used to show that a graph whose edge set decomposes into a Hamilton cycle and vertex-disjoint triangles is 3-choosable and that every planar graph has a matching whose deletion results in a 4-choosable graph. Interpolation formula for the coefficient: This method is in particular used to show that toroidal grids of even order are 3-choosable r-edge colourable r-regular planar graphs are r-edge choosable and complete graphs of order p+1 where p is a prime are p-edge choosable. Coefficients as the permanents of matrices: This method is in particular used in the study of the list version of vertex-edge weighting and to show that every graph is (2 3)-choosable. It is suited as a reference book for a graduate course in mathematics. | Combinatorial Nullstellensatz With Applications to Graph Colouring

GBP 52.99
1

The Role of Sustainability and Artificial Intelligence in Education Improvement

The Role of Sustainability and Artificial Intelligence in Education Improvement

This book is devoted to the issues faced by universities in the field of distance learning during and after COVID as well as in digitalization times. The book devotes a lot of space to the issues of Web 3. 0 in university e-learning Industry 4. 0 artificial intelligence and digital equity. The aim and scope of this book is to draw a holistic picture of education before and after COVID the psychological effects of COVID in education and using modern technologies application in education taking into consideration aspects of sustainability development Industry 4. 0 and Society 5. 0. The authors also raise the issue of artificial intelligence investigation in learner-instructor interaction. Features: To elaborate the functions of online education and numerous pedagogical strategies based on electronic learning to aid teachers and students with the tools required to succeed in the 21st century via engaging virtual experiences To analyze tools provided by Ed-Tech firms and the effect of digital tools on maintaining the educational process in times of crisis and after pandemic To create a roadmap for higher education institutions and provide tips regarding how to improve the effectiveness of the hybrid learning system To understand e-learning characteristic in the era of Industry 4. 0 and Society 5. 0 and characteristics of the different web generations To use AI applications to improve connections and relationships between students and teachers and in education in the future The book is both scientific and educational. It can be used at the university level and by anyone interested in the topics it covers. | The Role of Sustainability and Artificial Intelligence in Education Improvement

GBP 110.00
1

Introduction to Statistical Methods for Financial Models

Healthcare 4.0 Health Informatics and Precision Data Management

Python for Scientific Computing and Artificial Intelligence

Python for Scientific Computing and Artificial Intelligence

Python for Scientific Computing and Artificial Intelligence is split into 3 parts: in Section 1 the reader is introduced to the Python programming language and shown how Python can aid in the understanding of advanced High School Mathematics. In Section 2 the reader is shown how Python can be used to solve real-world problems from a broad range of scientific disciplines. Finally in Section 3 the reader is introduced to neural networks and shown how TensorFlow (written in Python) can be used to solve a large array of problems in Artificial Intelligence (AI). This book was developed from a series of national and international workshops that the author has been delivering for over twenty years. The book is beginner friendly and has a strong practical emphasis on programming and computational modelling. Features: No prior experience of programming is required Online GitHub repository available with codes for readers to practice Covers applications and examples from biology chemistry computer science data science electrical and mechanical engineering economics mathematics physics statistics and binary oscillator computing Full solutions to exercises are available as Jupyter notebooks on the Web Support Material GitHub Repository of Python Files and Notebooks: https://github. com/proflynch/CRC-Press/ Solutions to All Exercises: Section 1: An Introduction to Python: https://drstephenlynch. github. io/webpages/Solutions_Section_1. html Section 2: Python for Scientific Computing: https://drstephenlynch. github. io/webpages/Solutions_Section_2. html Section 3: Artificial Intelligence: https://drstephenlynch. github. io/webpages/Solutions_Section_3. html

GBP 52.99
1

Meaningful Futures with Robots Designing a New Coexistence

Meaningful Futures with Robots Designing a New Coexistence

Soon robots will leave the factories and make their way into living rooms supermarkets and care facilities. They will cooperate with humans in everyday life taking on more than just practical tasks. How should they communicate with us? Do they need eyes a screen or arms? Should they resemble humans? Or may they enrich social situations precisely because they act so differently from humans? Meaningful Futures with Robots: Designing a New Coexistence provides insight into the opportunities and risks that arise from living with robots in the future anchored in current research projects on everyday robotics. As well as generating ideas for robot developers and designers it also critically discusses existing theories and methods for social robotics from different perspectives - ethical design artistical and technological – and presents new approaches to meaningful human-robot interaction design. Key Features: Provides insights into current research on robots from different disciplinary angles with a particular focus on a value-driven design. Includes contributions from designers psychologists engineers philosophers artists and legal scholars among others. Licence line: Chapters 1 3 12 and 15 of this book are available for free in PDF format as Open Access from the individual product page at www. crcpress. com. They have been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4. 0 license. | Meaningful Futures with Robots Designing a New Coexistence

GBP 44.99
1

Introduction to Functional Data Analysis

Introduction to Functional Data Analysis

Introduction to Functional Data Analysis provides a concise textbook introduction to the field. It explains how to analyze functional data both at exploratory and inferential levels. It also provides a systematic and accessible exposition of the methodology and the required mathematical framework. The book can be used as textbook for a semester-long course on FDA for advanced undergraduate or MS statistics majors as well as for MS and PhD students in other disciplines including applied mathematics environmental science public health medical research geophysical sciences and economics. It can also be used for self-study and as a reference for researchers in those fields who wish to acquire solid understanding of FDA methodology and practical guidance for its implementation. Each chapter contains plentiful examples of relevant R code and theoretical and data analytic problems. The material of the book can be roughly divided into four parts of approximately equal length: 1) basic concepts and techniques of FDA 2) functional regression models 3) sparse and dependent functional data and 4) introduction to the Hilbert space framework of FDA. The book assumes advanced undergraduate background in calculus linear algebra distributional probability theory foundations of statistical inference and some familiarity with R programming. Other required statistics background is provided in scalar settings before the related functional concepts are developed. Most chapters end with references to more advanced research for those who wish to gain a more in-depth understanding of a specific topic.

GBP 44.99
1

Tidy Finance with R

Tidy Finance with R

This textbook shows how to bring theoretical concepts from finance and econometrics to the data. Focusing on coding and data analysis with R we show how to conduct research in empirical finance from scratch. We start by introducing the concepts of tidy data and coding principles using the tidyverse family of R packages. Code is provided to prepare common open-source and proprietary financial data sources (CRSP Compustat Mergent FISD TRACE) and organize them in a database. We reuse these data in all the subsequent chapters which we keep as self-contained as possible. The empirical applications range from key concepts of empirical asset pricing (beta estimation portfolio sorts performance analysis Fama-French factors) to modeling and machine learning applications (fixed effects estimation clustering standard errors difference-in-difference estimators ridge regression Lasso Elastic net random forests neural networks) and portfolio optimization techniques. Highlights 1. Self-contained chapters on the most important applications and methodologies in finance which can easily be used for the reader’s research or as a reference for courses on empirical finance. 2. Each chapter is reproducible in the sense that the reader can replicate every single figure table or number by simply copying and pasting the code we provide. 3. A full-fledged introduction to machine learning with tidymodels based on tidy principles to show how factor selection and option pricing can benefit from Machine Learning methods. 4. Chapter 2 on accessing and managing financial data shows how to retrieve and prepare the most important datasets financial economics: CRSP and Compustat. The chapter also contains detailed explanations of the most relevant data characteristics. 5. Each chapter provides exercises based on established lectures and classes which are designed to help students to dig deeper. The exercises can be used for self-studying or as a source of inspiration for teaching exercises. | Tidy Finance with R

GBP 59.99
1

Student Solutions Manual for Gallian's Contemporary Abstract Algebra

Student Solutions Manual for Gallian's Contemporary Abstract Algebra

Whereas many partial solutions and sketches for the odd-numbered exercises appear in the book the Student Solutions Manual written by the author has comprehensive solutions for all odd-numbered exercises and large number of even-numbered exercises. This Manual also offers many alternative solutions to those appearing in the text. These will provide the student with a better understanding of the material. This is the only available student solutions manual prepared by the author of Contemporary Abstract Algebra Tenth Edition and is designed to supplement that text. Table of Contents Integers and Equivalence Relations0. Preliminaries Groups1. Introduction to Groups 2. Groups 3. Finite Groups; Subgroups 4. Cyclic Groups 5. Permutation Groups 6. Isomorphisms 7. Cosets and Lagrange's Theorem 8. External Direct Products 9. Normal Subgroups and Factor Groups 10. Group Homomorphisms 11. Fundamental Theorem of Finite Abelian Groups Rings12. Introduction to Rings 13. Integral Domains14. Ideals and Factor Rings 15. Ring Homomorphisms 16. Polynomial Rings 17. Factorization of Polynomials 18. Divisibility in Integral Domains FieldsFields19. Extension Fields 20. Algebraic Extensions21. Finite Fields 22. Geometric Constructions Special Topics23. Sylow Theorems 24. Finite Simple Groups 25. Generators and Relations 26. Symmetry Groups 27. Symmetry and Counting 28. Cayley Digraphs of Groups 29. Introduction to Algebraic Coding Theory 30. An Introduction to Galois Theory 31. Cyclotomic Extensions Biography Joseph A. Gallian earned his PhD from Notre Dame. In addition to receiving numerous national awards for his teaching and exposition he has served terms as the Second Vice President and the President of the MAA. He has served on 40 national committees chairing ten of them. He has published over 100 articles and authored six books. Numerous articles about his work have appeared in the national news outlets including the New York Times the Washington Post the Boston Globe and Newsweek among many others. | Student Solutions Manual for Gallian's Contemporary Abstract Algebra

GBP 44.99
1

Combinatorics of Permutations

Combinatorics of Permutations

A CHOICE Outstanding Academic Title the first edition of this bestseller was lauded for its detailed yet engaging treatment of permutations. Providing more than enough material for a one-semester course Combinatorics of Permutations third edition continues to clearly show the usefulness of this subject for both students and researchers. The research in combinatorics of permutations has advanced rapidly since this book was published in a first edition. Now the third edition offers not only updated results it remains the leading textbook for a course on the topic. Coverage is mostly enumerative but there are algebraic analytic and topological parts as well and applications. Since the publication of the second edition there is tremendous progress in pattern avoidance (Chapters 4 and 5). There is also significant progress in the analytic combinatorics of permutations which will be incorporated. •A completely new technique from extremal combinatorics disproved a long-standing conjecture and this is presented in Chapter 4. •The area of universal permutations has undergone a lot of very recent progress and that has been noticed outside the academic community as well. This also influenced the revision of Chapter 5. •New results in stack sorting are added to Chapter 8. •Chapter 9 applications to biology has been revised. The author’s other works include Introduction to Enumerative and Analytic Combinatorics second edition (CHOICE Outstanding Academic Title) and Handbook of Enumerative Combinatorics published by CRC Press. The author also serves as Series Editor for CRC’s Discrete Mathematics and Its Applications.

GBP 99.99
1

Introduction to Mathematical Modeling and Computer Simulations

Python for Bioinformatics

Security and Resilience of Cyber Physical Systems

Security and Resilience of Cyber Physical Systems

In this era of 5G digital communication the implementation of industry 4. 0 is the need of the hour. The main aim of this industrial revolution is to completely automate the industry for better productivity correct decision making and increased efficiency. All the concepts of industry 4. 0 can only be implemented with the help of Cyber Physical System aka CPS. This is a smart system in which complete mechanism is monitored and controlled by computer-based algorithms. Confidentiality Integrity and Availability are the three major concern for providing the add on security to any organization or a system. It has become a biggest challenge among the security professionals to secure these cyber physical systems. Hackers and bad guys are planning various kinds of attacks on daily basis on these systems. This book addresses the various security and privacy issues involved in the cyber physical system. There is need to explore the interdisciplinary analysis to ensure the resilience of these systems including different types of cyber threats to these systems. The book highlights the importance of security in preventing detecting characterizing and mitigating different types of cyber threats on CPS. The book offers a simple to understand various organized chapters related to the CPS and their security for graduate students faculty research scholars and industry professionals. The book offers comprehensive coverage of the most essential topics including: Cyber Physical Systems and Industrial Internet of Things (IIoT) Role of Internet of Things and their security issues in Cyber Physical Systems. Role of Big data analytic to develop real time solution for CPS. DDoS attacks and their solutions in CPS. Emulator Mininet for simulating CPS. Spark-based DDoS Classification System for Cyber-Physical Systems | Security and Resilience of Cyber Physical Systems

GBP 89.99
1

Games Gambling and Probability An Introduction to Mathematics

Games Gambling and Probability An Introduction to Mathematics

Many experiments have shown the human brain generally has very serious problems dealing with probability and chance. A greater understanding of probability can help develop the intuition necessary to approach risk with the ability to make more informed (and better) decisions. The first four chapters offer the standard content for an introductory probability course albeit presented in a much different way and order. The chapters afterward include some discussion of different games different ideas that relate to the law of large numbers and many more mathematical topics not typically seen in such a book. The use of games is meant to make the book (and course) feel like fun! Since many of the early games discussed are casino games the study of those games along with an understanding of the material in later chapters should remind you that gambling is a bad idea; you should think of placing bets in a casino as paying for entertainment. Winning can obviously be a fun reward but should not ever be expected. Changes for the Second Edition: New chapter on Game Theory New chapter on Sports Mathematics The chapter on Blackjack which was Chapter 4 in the first edition appears later in the book. Reorganization has been done to improve the flow of topics and learning. New sections on Arkham Horror Uno and Scrabble have been added. Even more exercises were added! The goal for this textbook is to complement the inquiry-based learning movement. In my mind concepts and ideas will stick with the reader more when they are motivated in an interesting way. Here we use questions about various games (not just casino games) to motivate the mathematics and I would say that the writing emphasizes a just-in-time mathematics approach. Topics are presented mathematically as questions about the games themselves are posed. Table of Contents Preface1. Mathematics and Probability 2. Roulette and Craps: Expected Value 3. Counting: Poker Hands 4. More Dice: Counting and Combinations and Statistics 5. Game Theory: Poker Bluffing and Other Games 6. Probability/Stochastic Matrices: Board Game Movement 7. Sports Mathematics: Probability Meets Athletics 8. Blackjack: Previous Methods Revisited 9. A Mix of Other Games 10. Betting Systems: Can You Beat the System? 11. Potpourri: Assorted Adventures in Probability Appendices Tables Answers and Selected Solutions Bibliography Biography Dr. David G. Taylor is a professor of mathematics and an associate dean for academic affairs at Roanoke College in southwest Virginia. He attended Lebanon Valley College for his B. S. in computer science and mathematics and went to the University of Virginia for his Ph. D. While his graduate school focus was on studying infinite dimensional Lie algebras he started studying the mathematics of various games in order to have a more undergraduate-friendly research agenda. Work done with two Roanoke College students Heather Cook and Jonathan Marino appears in this book! Currently he owns over 100 different board games and enjoys using probability in his decision-making while playing most of those games. In his spare time he enjoys reading cooking coding playing his board games and spending time with his six-year-old dog Lilly. | Games Gambling and Probability An Introduction to Mathematics

GBP 82.99
1

Fundamentals of Ramsey Theory

Fundamentals of Ramsey Theory

Ramsey theory is a fascinating topic. The author shares his view of the topic in this contemporary overview of Ramsey theory. He presents from several points of view adding intuition and detailed proofs in an accessible manner unique among most books on the topic. This book covers all of the main results in Ramsey theory along with results that have not appeared in a book before. The presentation is comprehensive and reader friendly. The book covers integer graph and Euclidean Ramsey theory with many proofs being combinatorial in nature. The author motivates topics and discussion rather than just a list of theorems and proofs. In order to engage the reader each chapter has a section of exercises. This up-to-date book introduces the field of Ramsey theory from several different viewpoints so that the reader can decide which flavor of Ramsey theory best suits them. Additionally the book offers: A chapter providing different approaches to Ramsey theory e. g. using topological dynamics ergodic systems and algebra in the Stone-Čech compactification of the integers. A chapter on the probabilistic method since it is quite central to Ramsey-type numbers. A unique chapter presenting some applications of Ramsey theory. Exercises in every chapter The intended audience consists of students and mathematicians desiring to learn about Ramsey theory. An undergraduate degree in mathematics (or its equivalent for advanced undergraduates) and a combinatorics course is assumed. TABLE OF CONENTS Preface List of Figures List of Tables Symbols 1. Introduction 2. Integer Ramsey Theory 3. Graph Ramsey Theory 4. Euclidean Ramsey Theory 5. Other Approaches to Ramsey Theory 6. The Probabilistic Method 7. Applications Bibliography Index Biography Aaron Robertson received his Ph. D. in mathematics from Temple University under the guidance of his advisor Doron Zeilberger. Upon finishing his Ph. D. he started at Colgate University in upstate New York where he is currently Professor of Mathematics. He also serves as Associate Managing editor of the journal Integers. After a brief detour into the world of permutation patterns he has focused most of his research on Ramsey theory. | Fundamentals of Ramsey Theory

GBP 82.99
1

Applied Categorical and Count Data Analysis

Applied Categorical and Count Data Analysis

Developed from the authors’ graduate-level biostatistics course Applied Categorical and Count Data Analysis Second Edition explains how to perform the statistical analysis of discrete data including categorical and count outcomes. The authors have been teaching categorical data analysis courses at the University of Rochester and Tulane University for more than a decade. This book embodies their decade-long experience and insight in teaching and applying statistical models for categorical and count data. The authors describe the basic ideas underlying each concept model and approach to give readers a good grasp of the fundamentals of the methodology without relying on rigorous mathematical arguments. The second edition is a major revision of the first adding much new material. It covers classic concepts and popular topics such as contingency tables logistic regression models and Poisson regression models along with modern areas that include models for zero-modified count outcomes parametric and semiparametric longitudinal data analysis reliability analysis and methods for dealing with missing values. As in the first edition R SAS SPSS and Stata programming codes are provided for all the examples enabling readers to immediately experiment with the data in the examples and even adapt or extend the codes to fit data from their own studies. Designed for a one-semester course for graduate and senior undergraduate students in biostatistics this self-contained text is also suitable as a self-learning guide for biomedical and psychosocial researchers. It will help readers analyze data with discrete variables in a wide range of biomedical and psychosocial research fields. Features: Describes the basic ideas underlying each concept and model Includes R SAS SPSS and Stata programming codes for all the examples Features significantly expanded Chapters 4 5 and 8 (Chapters 4-6 and 9 in the second edition Expands discussion for subtle issues in longitudinal and clustered data analysis such as time varying covariates and comparison of generalized linear mixed-effect models with GEE

GBP 74.99
1

Financial Mathematics Two Volume Set

Financial Mathematics Two Volume Set

This textbook provides complete coverage of discrete-time financial models that form the cornerstones of financial derivative pricing theory. Unlike similar texts in the field this one presents multiple problem-solving approaches linking related comprehensive techniques for pricing different types of financial derivatives. Key features: In-depth coverage of discrete-time theory and methodology. Numerous fully worked out examples and exercises in every chapter. Mathematically rigorous and consistent yet bridging various basic and more advanced concepts. Judicious balance of financial theory mathematical and computational methods. Guide to Material. This revision contains: Almost 200 pages worth of new material in all chapters. A new chapter on elementary probability theory. An expanded the set of solved problems and additional exercises. Answers to all exercises. This book is a comprehensive self-contained and unified treatment of the main theory and application of mathematical methods behind modern-day financial mathematics. Table of Contents List of Figures and Tables Preface I Introduction to Pricing and Management of Financial Securities 1 Mathematics of Compounding 2 Primer on Pricing Risky Securities 3 Portfolio Management 4 Primer on Derivative Securities II Discrete-Time Modelling 5 Single-Period Arrow–Debreu Models 6 Introduction to Discrete-Time Stochastic Calculus 7 Replication and Pricing in the Binomial Tree Model 8 General Multi-Asset Multi-Period Model Appendices A Elementary Probability Theory B Glossary of Symbols and Abbreviations C Answers and Hints to Exercises References Index Biographies Giuseppe Campolieti is Professor of Mathematics at Wilfrid Laurier University in Waterloo Canada. He has been Natural Sciences and Engineering Research Council postdoctoral research fellow and university research fellow at the University of Toronto. In 1998 he joined the Masters in Mathematical Finance as an instructor and later as an adjunct professor in financial mathematics until 2002. Dr. Campolieti also founded a financial software and consulting company in 1998. He joined Laurier in 2002 as Associate Professor of Mathematics and as SHARCNET Chair in Financial Mathematics. Roman N. Makarov is Associate Professor and Chair of Mathematics at Wilfrid Laurier University. Prior to joining Laurier in 2003 he was an Assistant Professor of Mathematics at Siberian State University of Telecommunications and Informatics and a senior research fellow at the Laboratory of Monte Carlo Methods at the Institute of Computational Mathematics and Mathematical Geophysics in Novosibirsk Russia. | Financial Mathematics Two Volume Set

GBP 130.00
1

Handbook of Statistics in Clinical Oncology

Handbook of Statistics in Clinical Oncology

Many new challenges have arisen in the area of oncology clinical trials. New cancer therapies are often based on cytostatic or targeted agents which pose new challenges in the design and analysis of all phases of trials. The literature on adaptive trial designs and early stopping has been exploding. Inclusion of high-dimensional data and imaging techniques have become common practice and statistical methods on how to analyse such data have been refined in this area. A compilation of statistical topics relevant to these new advances in cancer research this third edition of Handbook of Statistics in Clinical Oncology focuses on the design and analysis of oncology clinical trials and translational research. Addressing the many challenges that have arisen since the publication of its predecessor this third edition covers the newest developments involved in the design and analysis of cancer clinical trials incorporating updates to all four parts: Phase I trials: Updated recommendations regarding the standard 3 + 3 and continual reassessment approaches along with new chapters on phase 0 trials and phase I trial design for targeted agents. Phase II trials: Updates to current experience in single-arm and randomized phase II trial designs. New chapters include phase II designs with multiple strata and phase II/III designs. Phase III trials: Many new chapters include interim analyses and early stopping considerations phase III trial designs for targeted agents and for testing the ability of markers adaptive trial designs cure rate survival models statistical methods of imaging as well as a thorough review of software for the design and analysis of clinical trials. Exploratory and high-dimensional data analyses: All chapters in this part have been thoroughly updated since the last edition. New chapters address methods for analyzing SNP data and for developing a score based on gene expression data. In addition chapters on risk calculators and forensic bioinformatics have been added. Accessible to statisticians and oncologists interested in clinical trial methodology the book is a single-source collection of up-to-date statistical approaches to research in clinical oncology.

GBP 52.99
1

Multiple Imputation in Practice With Examples Using IVEware

Summability Theory and Its Applications

The Global Politics of Artificial Intelligence

Algorithm Design: A Methodological Approach - 150 problems and detailed solutions