Mitochondrial Dynamics and Uncoupling Protein 2 In The Hippocampus - MD Mahdi Hasan

Mitochondria are a crucial site of energy metabolism in neurons. The energy demand is higher in neurons than in most other cells, which is reflected by high consumption of oxygen in the brain. In neurodegenerative pathology, reactive oxygen species (ROS) may lead to oxidative stress and mitochondrial DNA (mtDNA) damage. The transgenic mutated uracil-DNA glycosylase 1 (mutUNG1) mice express the mutUNG1 enzyme, which induces mitochondrial toxicity, caused by high numbers of apurinic/apyrimidinic-sites..