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Patch-Clamp Applications and Protocols - - Bog - Humana Press Inc. - Plusbog.dk

The first part of Patch-Clamp Applications and Protocols presents modern developments associated with the techn- ogy of patch-clamp electrodes, of cell-free ion channel reco- ing, and of the whole-cell patch-clamp technique.

DKK 816.00

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Patch Clamp Technique - - Bog - Callisto Reference - Plusbog.dk

Patch Clamp Technique - - Bog - Callisto Reference - Plusbog.dk - vi har over 400.000 produkter på webshoppen. Fri fragt og fremragende score på TP

DKK 1049.00

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Advanced Patch-Clamp Analysis for Neuroscientists - - Bog - Humana Press Inc. - Plusbog.dk

Chapters focus on in-vivo recordings, voltage-gated channel recording and analysis, dendritic and axonal recordings, synaptic current recording and analysis, advanced fluorescent techniques, optogenetics and voltage-sensitive dye imaging, and finally channel and neuronal modeling.

DKK 901.00

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Patch Clamping - Areles Molleman - Bog - John Wiley & Sons Inc - Plusbog.dk

Patch clamping is a widely applied electrophysiological technique for the study of ion channels; membrane proteins that regulate the flow of ions across cellular membranes and therefore influence the physiology of all cells. Patch Clamping aims to cover the basic principles and practical applications of this important technique. Starting with a review of the history of patch clamping, the text then goes on to cover the basic principles, platforms, equipment and environmental control, and will also include coverage of preparation types, recording modes and analysis of results. - - This book will explain the basic principles and practical application of patch clamp electrophysiology - - Written in a non-technical style to ensure its broad appeal to novice users - - Takes a practical approach - - This self-contained guide provides everything a practising patch clamp electrophysiologist needs to know to master this technique, including an overview of membrane biophysics, standard experimental design, data analysis, and technical concerns -

DKK 1198.00

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Circumcision - - Bog - IntechOpen - Plusbog.dk

Male circumcision has been practiced since the dawn of human culture and may be performed for medical and non-medical reasons. Although a simple procedure, if not properly performed it may lead to minor or even serious complications, such as urethral or glanular injury. Circumcision is performed using various techniques, including the classic open technique, clamp technique, and laser /electrocautery technique, with various outcomes in terms of safety. The debate over the pros and cons of cultural circumcision continues, with experts in the field holding divergent opinions.The purpose of this book is to present an overview of the historical background of male circumcision and to describe different circumcision techniques.

DKK 1037.00

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PINSTRIPE PATRONAGE - Martin Tolchin - Bog - Taylor & Francis Inc - Plusbog.dk

Political patronage - awarding discretionary favors in exchange for political support - is alive and well in 21st century America. This book examines the little understood patronage system, showing how it is used by ''pinstripe'' elites to subvert the democratic process. ''Pinstripe patronage'' thrives on the billions of dollars distributed by government for the privatisation of public services. Martin and Susan Tolchin introduce us to government grants specified for the use of an individual, corporation, or community and ''hybrid agencies'', with high salaries for top executives and board members. In return for this corporate welfare pinstipe partons giving politicians the ever-increasing funds needed to conduct their political campaigns. As budget cuts begin to bite, the authors argue that it is time to clamp down on the corrupt practice of pinstripe patronage.

DKK 1211.00

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Textbook of Ion Channels Volume I - - Bog - Taylor & Francis Ltd - Plusbog.dk

The Textbook of Ion Channels is a set of three volumes providing a wide-ranging reference source on ion channels for students, instructors and researchers. Ion channels are membrane proteins that control the electrical properties of neurons and cardiac cells; mediate the detection and response to sensory stimuli like light, sound, odor, and taste; and regulate the response to physical stimuli like temperature and pressure. In non-excitable tissues, ion channels are instrumental for the regulation of basic salt balance that is critical for homeostasis. Ion channels are located at the surface membrane of cells, giving them the unique ability to communicate with the environment, as well as the membrane of intracellular organelles, allowing them to regulate internal homeostasis. Ion channels are fundamentally important for human health and diseases, and are important targets for pharmaceuticals in mental illness, heart disease, anesthesia, pain and other clinical applications. The modern methods used in their study are powerful and diverse, ranging from single ion-channel measurement techniques to models of ion channel diseases in animals, and human clinical trials for ion channel drugs. Volume I, Part 1 covers fundamental topics such as the basic principles of ion permeation and selectivity, voltage-dependent, ligand-dependent, and mechano-dependent ion channel activation mechanisms, the mechanisms for ion channel desensitization and inactivation, and basic ion channel pharmacology and inhibition. Volume I, Part 2 offers a practical guide of cardinal methods for researching ion channels, including heterologous expression and voltage-clamp and patch-clamp electrophysiology; isolation of native currents using patch clamping; modeling ion channel gating, structures, and its dynamics; crystallography and cryo-electron microscopy; fluorescence and paramagnetic resonance spectroscopy methods; and genetics approaches in model organisms. All three volumes give the reader an introduction to fundamental concepts needed to understand the mechanism of ion channels; a guide to the technical aspects of ion channel research; a modern guide to the properties of major ion channel families; and includes coverage of key examples of regulatory, physiological and disease roles for ion channels.

DKK 995.00

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From Molecules to Networks - - Bog - Elsevier Science Publishing Co Inc - Plusbog.dk

An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. The third edition of From Molecules to Networks provides the solid foundation of the morphological, biochemical, and biophysical properties of nerve cells. In keeping with previous editions, the unique content focus on cellular and molecular neurobiology and related computational neuroscience is maintained and enhanced. All chapters have been thoroughly revised for this third edition to reflect the significant advances of the past five years. The new edition expands on the network aspects of cellular neurobiology by adding new coverage of specific research methods (e.g., patch-clamp electrophysiology, including applications for ion channel function and transmitter release; ligand binding; structural methods such as x-ray crystallography). Written and edited by leading experts in the field, the third edition completely and comprehensively updates all chapters of this unique textbook and insures that all references to primary research represent the latest results.

DKK 875.00

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Social Media and Politics in Africa - - Bog - Bloomsbury Publishing PLC - Plusbog.dk

The smartphone and social media have transformed Africa, allowing people across the continent to share ideas, organise, and participate in politics like never before. While both activists and governments alike have turned to social media as a new form of political mobilization, some African states have increasingly sought to clamp down on the technology, introducing restrictive laws or shutting down networks altogether.Drawing on over a dozen new empirical case studies – from Kenya to Somalia, South Africa to Tanzania – this collection explores how rapidly growing social media use is reshaping political engagement in Africa. But while social media has often been hailed as a liberating tool, the book demonstrates how it has often served to reinforce existing power dynamics, rather than challenge them.Featuring experts from a range of disciplines from across the continent, this collection is the first comprehensive overview of social media and politics in Africa. By examining the historical, political, and social context in which these media platforms are used, the book reveals the profound effects of cyber-activism, cyber-crime, state policing and surveillance on political participation.

DKK 814.00

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The Annotated Hodgkin and Huxley - David L. Ferster - Bog - Princeton University Press - Plusbog.dk

The first annotated edition of the scientific papers that created the foundation of modern neuroscience and physiology The origin of everything known about how neurons and muscles generate electrical signals can be traced back to five revolutionary papers, published in the Journal of Physiology in 1952 by Alan Hodgkin and Andrew Huxley. The principles they revealed remain cornerstones of the discipline, summarized in every introductory neuroscience and physiology course. Since that era, however, scientific practice, technology, and presentation have changed extensively. It is difficult for the modern reader to appreciate Hodgkin and Huxley’s rigorous scientific thought, elegant experimental design, ingenious analysis, and beautiful writing. This book provides the first annotated edition of these papers, offering essential background on everything, from terminology, equations, and electronics, to the greater historical and scientific context surrounding the work. The original journal pages are displayed opposite detailed notes explaining content, process, and background, with copies of the figures replotted according to modern conventions. Indispensable for scientists, teachers, and trainees alike, The Annotated Hodgkin and Huxley makes an essential body of knowledge—and an unparalleled approach to research—accessible to a new generation of readers. Reproduces the original articles paired with extensive annotations on facing pagesReplots figures with modern conventions of data displayExplains the development of the voltage clamp and the discovery of ionic currents and action potential generation, foundational to the study of neuroscience and physiologySummarizes the history of electrophysiology leading to Hodgkin and Huxley’s workIncludes appendices on relevant concepts from mathematics, physics, electronics, chemical kinetics, and numerical methods

DKK 854.00

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Galvani's Spark - Alan Mccomas - Bog - Oxford University Press Inc - Plusbog.dk

Galvani''s Spark chronicles the gradual understanding of the nerve impulse which is the basis of all thoughts, sensations and actions. The story begins with Luigi Galvani''s chance observation of a spark from a friction machine causing a frog''s leg to twitch from across the room. The accurate recording and the understanding of the properties of the nerve fiber membrane that makes the impulse possible became the objectives of neuroscientists for over 200 years. The author, Alan J. McComas finely interweaves the stories, the challenges, and the controversies of the most prominent figures in neuroscience, from the histological descriptions of nerve cells by Cajal to the discovery of a three-dimensional structure of ion channels in cell membranes by MacKinnon. Along the way he details the first recordings of the impulse with a cathode ray oscilloscope by Gasser and Erlanger, Adrian''s discovery that stimulus intensity is coded by the frequency of nerve impulses, and Hodgkin and Huxley''s brilliant voltage clamp experiments, amongst many others. The recognition by Galvani that muscles and nerves have an electrical component triggered the field of neurophysiology and in turn has produced some of the greatest discoveries in neuroscience. 16 investigators of the nerve impulse went on to win or share Nobel prizes and this book not only emphasizes their work but also traces their brilliant careers. For anyone interested in the nervous system and the history of neuroscience, Galvani''s Spark: The Story of the Nerve Impulse is essential reading.

DKK 1018.00

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